Metabolic Resilience & Performance Support

Overview

• 16–amino-acid mitochondrial-encoded peptide (from the 12S rRNA gene, MTRNR1)

• Investigated for roles in metabolic flexibility, insulin signaling, and exercise adaptation

• Research compound supported by preclinical and early human studies

• Investigational outside approved medical indications

Core Actions

• Activates cellular energy pathways

  • Promotes AMPK signaling for efficient fuel utilization and metabolic by-product clearance

• Supports insulin sensitivity

  • Improves glucose uptake and metabolic signaling in research models

• Enhances exercise adaptation

  • Levels increase with training; associated with improved exercise tolerance and recovery signaling

• Supports healthy body composition

  • Encourages fat oxidation and limits fat accumulation in animal models

• Supports metabolic resilience

  • Aids cellular adaptation to metabolic and oxidative stress

Mechanism of Action (At a Glance)

• AMPK pathway activation

  • Stimulates glucose uptake, fatty-acid oxidation, and mitochondrial biogenesis signaling

• Folate / one-carbon metabolism interface

  • Influences cellular redox balance and stress-response pathways

• Exercise-inducible mitokine signaling

  • Acts as a nucleus-directed signal regulating metabolic gene expression

Key Research-Based Benefits*

• Cellular energy and mitochondrial support

• Insulin sensitivity and glucose regulation

• Exercise performance and recovery signaling

• Fat metabolism and metabolic flexibility

• Healthy aging metabolic context

*Based on cell, animal, and early human research. MOTS-c remains investigational and is not approved for medical use.

Format & Handling

• Delivery: Dual-chamber Snap Pen (lyophilized peptide and bacteriostatic diluent separated)

• Activation: Twist to snap internal seal, gently invert to mix, prime, and dispense per protocol

• Storage: Refrigerate before and after activation; avoid repeated freeze–thaw cycles

• Quality: High-purity material, low endotoxin, COA and SDS supplied per batch, cold-chain fulfillment

Technical Information

• CAS: 1627580-64-6

• PubChem CID: 146675088

• Molecular Formula: C101H152N28O22S2

• Synonyms: MOTS-c, Mots-c, UNII-A5CV6JFB78, MOTS-c (human) (trifluoroacetate salt), A5CV6JFB78